Extended Data Fig. 6: Cas9 status.

Parental line is the original cell line with no modifications. Cas9 cell line is a polyclonal cell line expressing Cas9 (used for all CRISPR and one compound experiment). This UMAP plot includes the CPJUMP1 primary experiment (4 Compound, 4 CRISPR and 2 ORF plates per cell type and time point) plus all other data points from the CPJUMP1 experiments, as outlined in Fig. 3.