Extended Data Fig. 8: CoNGA, TCRdist results and identification of TCR analogs. | Nature Methods

Extended Data Fig. 8: CoNGA, TCRdist results and identification of TCR analogs.

From: De novo identification of CD4+ T cell epitopes

Extended Data Fig. 8

The top three row of the CoNGA panel shows the GEX and TCR clusters with phenotype marker expression in each cluster. The TCR logo panel shows TCR clusters with logo representations of the TCRs that form these clusters. The purple, red, and blue rectangles indicate the TCR4 CoNGA cluster, TCR30 CoNGA cluster, and TCR11 gene expression clusters respectively. Each cluster’s TCRs which were selected for validation are listed in the tables below with the parental TCR. TCRs which lack GEX clusters in the TCR30 analog table were selected for validation by similarity determined through GLIPH2. TCR6B is not depicted in the figure because of the minimum clone size requirement for CoNGA, TCR11 mouse IDs are lost during CoNGA processing.

Back to article page