A systematic comparison of 11 sequencing-based spatial transcriptomics methods reveals molecular diffusion as a critical variable that influences the effective resolution and data interpretation across platforms. Our benchmarking study should aid biologists in selecting the most appropriate method for their specific tissue.
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References
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This is a summary of: You, Y. et al. Systematic comparison of sequencing-based spatial transcriptomic methods. Nat. Methods https://doi.org/10.1038/s41592-024-02325-3 (2024).
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Advancing sequencing-based spatial transcriptomics with a comprehensive benchmarking study. Nat Methods 21, 1589–1590 (2024). https://doi.org/10.1038/s41592-024-02326-2
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DOI: https://doi.org/10.1038/s41592-024-02326-2