Fig. 4: Annotations for proofreadable datasets.

a, Spatial points can be used to capture a huge diversity of biological metadata generated by either human annotators or machine algorithms. Additional metadata for existing CAVE annotations can be added with reference annotations that avoid duplicating existing annotations (illustrated as dashed lines). b, The annotation services handle all annotations through a generic workflow that depends only on expressing all annotations as collections of spatial points and associated metadata. Spatial annotations mark the location of a feature, such as a spine head. Scale bar, 500 nm. c, The materialization service retrieves the supervoxel ID underlying all spatial points. d, This enables the materialization service to look up the root ID underneath that points at any given moment in time using the ChunkedGraph. e, Illustration of how the mapping from supervoxel ID to segment ID changed the annotation due to proofreading (octree levels not shown). The changes are tracked in a lineage graph of the altered roots.