Extended Data Fig. 1: Design of the large-display version of Moculus (Moculus-XL) with a rotating treadmill (Gramophone) and validation with retinotopic mapping.
From: Moculus: an immersive virtual reality system for mice incorporating stereo vision
a, Photo of Moculus-XL with the Gramophone. b, 3D rendering of Moculus-XL with a model mouse. c, 3D rendering of Moculus-XL with a head-fixed mouse model, showing a craniotomy window and headplate. d, 3D rendering highlighting the headplate and headplate-holder components with the Gramophone and Moculus-XL. e, SolidWorks model of Moculus-XL from a different angle, with two 3D-printed alignment plates (turquoise). f, Exploded view of Moculus-XL showing components like the mount, microdisplay, display holder, ½’ lens, and headplate. The molded silicone shading material is omitted for clarity. g, Optical path of Moculus-XL, including a plano-convex lens (NBK-7, diameter of 12.7 mm and focal length of 25 mm) and a mouse eye model. h, Lateral view of Moculus-XL with an enucleated albino mouse eye. i, Different types of distortion corrections implemented into the Moculus software. j, Rendered images to compare the large (V1, Moculus-XL) and compact (V2, Moculus-S) versions. k, Moculus-S compared in size to a coin (100 Hungarian Forint) that is similar in diameter (23.8 mm) to a quarter dollar (24.3 mm). l-r, Retinotopic mapping. l, A bar with a chessboard pattern moved vertically or horizontally at 0.5 Hz. m, Neuronal responses were recorded using multi-layer imaging (3–5 layers) in V1, with a field of-view of 460–580 µm. The image shows an example layer. n, Example of automatically detected neurons from the single layer shown in panel m. o, Neuronal responses to bar movement along the x or y axis. Each curve shows the average response of a cell over 45 repetitions. Only cells with a signal-to-noise ratio over four are included. p, Average x and y response traces from panel o are projected onto displays, showing the response amplitudes where the bars passed. q, Measurements were repeated with bars moving in both directions to avoid response effects. Blue curves are for left-to-right and top-to-bottom movements; black curves are for right-to-left and bottom-to-top movements. r, Same projection as panel p but for measurements shown in panel q.
