Extended Data Fig. 5: Characterization of cell type-specific enhancers identified by ChAIR. | Nature Methods

Extended Data Fig. 5: Characterization of cell type-specific enhancers identified by ChAIR.

From: Tri-omic single-cell mapping of the 3D epigenome and transcriptome in whole mouse brains throughout the lifespan

Extended Data Fig. 5: Characterization of cell type-specific enhancers identified by ChAIR.The alternative text for this image may have been generated using AI.

(a) The matrix of ATAC signals at cell type-specific enhancer loci (n = 562) across 9 cell groups. (b) Genomic annotations. (c) Chromatin states annotated by ChromHMM. (d-e) Number of enhancers in different cell groups (d) and number of associated cell type-specific marker genes (e). (f) Distances from enhancers to their nearest genes and to the targeted marker genes. The P value was calculated using the two-sided Wilcoxon test. (g-h) Numbers of enhancers represented in each cell group (g) and associated with each target gene (h). (i-j) Mean distance of enhancer to target genes in different cell groups (i) and for individual genes (j). Center line in violin plot indicates median, asterisk indicates average, box represents interquartile range (25th to 75th percentiles), and whiskers extend to 1.5× interquartile range.

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