Extended Data Fig. 6: Assessment of the impact of common image artifacts on spot detection performance.

For a test image of the HybISS dataset an increasing number of different types of artifacts were introduced. Shown is the F1 score for Spotiflow and LoG. a) Hot pixels. b) Uneven illumination, which may cause vignetting effects. c) Vertical-striped noise. Results show the F1 score (higher is better) for different levels.