Extended Data Fig. 4: Relations of M1/M2 polarization latent factors with metadata. | Nature Methods

Extended Data Fig. 4: Relations of M1/M2 polarization latent factors with metadata.

From: Single-cell ultra-high-throughput multiplexed chromatin and RNA profiling reveals gene regulatory dynamics

Extended Data Fig. 4: Relations of M1/M2 polarization latent factors with metadata.

a, Left: Percentage of variance explained by each MOFA-inferred latent factor in RNA and ATAC modalities for M0/M1 cells (top) and M0/M2 cells (bottom). Right: Correlation between latent factors and metadata, represented by dot plots for M0/M1 cells (top) and M0/M2 cells (bottom). Dot color indicates the Pearson correlation coefficient, and dot size reflects statistical significance (FDR corrected p-value). b, Distributions of cells from each time point across MOFA factor weights associated with M1 polarization (left) and M2 polarization (right). c, MOFA denoised gene expression of RBP-J per timepoint for M0 and M2 polarized cells. Center line of boxplots represent median; lower and upper hinges represent the 25th and 75th quartiles respectively. Whiskers represent values that fall within 1.5 times the interquartile range between the 25th and 75th percentiles.

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