Extended Data Fig. 1: Subclone detection and differential gene analysis an invasive ductal carcinoma sample.
From: Cancer subclone detection based on DNA copy number in single-cell and spatial omic sequencing data
a. Subclones detected from Clonalscope on the ST dataset from an invasive ductal carcinoma sample and paired spot-level pathologist annotation. b. The mean copy number profiles across the cells assigned to the three spatially segregated subclones (bottom), and the density plots of four regions with differences in the copy number states for at least one of the three subclones (top). c, d. show the top 6 highly expressed genes for tumor subclones 2 and 3. The color scale indicates log-normalized UMI counts for each gene.
