Fig. 4: Application of GHIST to TCGA breast cancer H&E images.
From: Spatial gene expression at single-cell resolution from histology using deep learning with GHIST
a, Illustration of the capacity of GHIST to predict gene expression for each cell in an H&E WSI (example from two TCGA-BRCA samples, TCGA-AN-A0XP and TCGA-C8-A1HF). b, Visualization of the predicted cell type on the two selected TCGA samples. A UMAP visualization is used to project the cells on a two-dimensional plot. A malignant cell-type marker EPCAM and a stromal cell-type marker SFRP4 are used to visualize the GHIST-predicted location of the two cell types. c, Predicted cell-type proportions for the selected TCGA HER2+ individuals.
