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From slices to deep dishes: spatial transcriptomics and translatomics of thick tissue blocks

Nature Methods volume 22, pages 2500–2502 (2025)Cite this article

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Deep-STARmap and Deep-RIBOmap improve spatial transcriptomic and translatomic methods by increasing performance in thick, intact tissue blocks.

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Fig. 1: Schematic representation of Deep-STARmap.

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Acknowledgements

S.V. acknowledges funding from the Knut and Alice Wallenberg Foundation, Science for Life Laboratory, Bill and Melinda Gates Foundation and MacMillan Center for the Study of the Non-coding Cancer Genome. S.V. is supported as a Wallenberg Academy Fellow and SciLifeLab Fellow at Uppsala University.

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Authors and Affiliations

  1. New York Genome Center, New York, NY, USA

    Maroš Pleška & Sanja Vickovic

  2. Department of Biomedical Engineering and Herbert Irving Institute for Cancer Dynamics, Columbia University, New York, NY, USA

    Sanja Vickovic

  3. Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden

    Sanja Vickovic

Authors
  1. Maroš Pleška
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  2. Sanja Vickovic
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Correspondence to Sanja Vickovic.

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The authors declare no competing interests.

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Pleška, M., Vickovic, S. From slices to deep dishes: spatial transcriptomics and translatomics of thick tissue blocks. Nat Methods 22, 2500–2502 (2025). https://doi.org/10.1038/s41592-025-02815-y

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