Extended Data Fig. 7: Cell-cell interactions and multivalent immune cell niches.
From: Highly multiplexed 3D profiling of cell states and immune niches in human tumors
a, Surface rendering of Fig. 6e. b, Maximum projection of tertiary lymphoid structures in the VGP tumour region. Dashed lines demarcate colonies of CD20 + B cells (cyan) mixed with CD11c+ dendritic cells (yellow). White box indicates zoom in version found in Fig. 6l. Scale bar 100 μm. c, A l membrane intensity profile depicting CD4 (cyan) and CD8 (magenta) average expression across membranes of cells 4 (CD8 T cell) and 5 (CD4 T cell) from Fig. 6p. Solid lines represent raw data and dashed lines polynomial curve fitting. Red ‘X’s mark the maximum intensity along membrane intensity profiles and denote the midpoint of the cell membrane for each channel.
