Modeling cellular responses to developmental and chemical cues is essential for understanding disease progression and informing therapeutic strategies, yet it often demands extensive experimental screening. We have developed a conditional diffusion model called Squidiff, which enables the in silico prediction of single-cell transcriptomic responses to both developmental signals and perturbations.
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This is a summary of: He, S. et al. Squidiff: predicting cellular development and responses to perturbations using a diffusion model. Nat. Methods https://doi.org/10.1038/s41592-025-02877-y (2025).
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Predicting cellular responses with conditional diffusion models. Nat Methods 23, 24–25 (2026). https://doi.org/10.1038/s41592-025-02878-x
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DOI: https://doi.org/10.1038/s41592-025-02878-x
