Extended Data Fig. 5: Cell type specificity of multicellular programs and MCP2 gene scores. | Nature Methods

Extended Data Fig. 5: Cell type specificity of multicellular programs and MCP2 gene scores.

From: Pertpy: an end-to-end framework for perturbation analysis

Extended Data Fig. 5: Cell type specificity of multicellular programs and MCP2 gene scores.The alternative text for this image may have been generated using AI.

(a) Pair plots for MCP 2. The kernel density estimate along the diagonal shows the average score for each MCP by sample, specific to the indicated cell type. In the lower triangle’s scatter plots, each point signifies the average measurement from a patient for the cell types denoted by the respective row (x-axis) and column (y-axis). MCP 2 separates poor response to the PDL-1 inhibitors. (b) MCP 2 extrema genes per cell type. Shown are the respective five genes with the highest and lowest scores for MCP 2. HSPA1B, which is significantly increased in MCP2 for all tested cell types (Methods), has been previously identified as a prognostic biomarker in breast cancer91,92.

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