We introduce TransBrain, a computational framework for bidirectional translation of whole-brain phenotypes between humans and mice. TransBrain enables quantitative cross-species comparison in a unified latent space and facilitates functional modeling of the human brain in mouse models.
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This is a summary of: Huang, S. et al. TransBrain: a computational framework for translating brain-wide phenotypes between humans and mice. Nat. Methods https://doi.org/10.1038/s41592-025-02961-3 (2025).
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Whole-brain phenotype mapping between humans and mice. Nat Methods 23, 295–296 (2026). https://doi.org/10.1038/s41592-025-02963-1
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DOI: https://doi.org/10.1038/s41592-025-02963-1
