Most scientific instruments currently discard rich streams of commands, data and metadata from which AI systems could learn to conduct experiments with expert-level decision-making and troubleshooting skills. Recording and using this data at scale requires rethinking what data to store, incentivizing large-scale cooperation, and determining how to quantify the reliability of such autonomous systems.
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References
Vaswani, A. et al. Attention is all you need. In Advances in Neural Information Processing Systems Vol. 30 (eds. Guyon, I. et al.) https://proceedings.neurips.cc/paper_files/paper/2017/file/3f5ee243547dee91fbd053c1c4a845aa-Paper.pdf (Curran, 2017).
Henighan, T. et al. Preprint at arXiv https://doi.org/10.48550/arXiv.2010.14701 (2020).
Jumper, J. et al. Nature 596, 583–589 (2021).
Kim, M. J. et al. Preprint at arXiv https://doi.org/10.48550/arXiv.2406.09246 (2024).
OECD. Artificial Intelligence in Science: Challenges, Opportunities and the Future of Research https://www.oecd.org/en/publications/artificial-intelligence-in-science_a8d820bd-en.html (OECD, 2023).
Boiko, D. A., MacKnight, R., Kline, B. & Gomes, G. Nature 624, 570–578 (2023).
Szymanski, N. J. et al. Nature 624, 86–91 (2023).
Eisenstein, M. Nat. Methods 17, 1075–1079 (2020).
Carpenter, A. E., Cimini, B. A. & Eliceiri, K. W. Nat. Methods 20, 962–964 (2023).
Griffin, C., Wallace, D., Mateos-Garcia, J., Schieve, H. & Kohli, P. A new golden age of discovery: seizing the AI for Science opportunity. AI Policy Perspectives https://www.aipolicyperspectives.com/p/a-new-golden-age-of-discovery (2024).
Villalobos, P. et al. Preprint at arXiv https://doi.org/10.48550/arXiv.2211.04325 (2024).
Manning, C., Raghavan, P. & Schuetze, H. Introduction to Information Retrieval (Cambridge Univ. Press, 2009).
Zulueta-Coarasa, T. et al. Nat. Methods 22, 2245–2252 (2025).
Skowronek, P., Nawalgaria, A. & Mann, M. Preprint at bioRxiv https://doi.org/10.1101/2025.10.05.680425 (2025).
Douillard, A. et al. Preprint at arXiv https://doi.org/10.48550/arXiv.2311.08105 (2023).
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We thank Ivo Vellekoop for discussions.
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H.P. and N.N. conceived the project and wrote the manuscript together.
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Pinkard, H., Norlin, N. The missing data for intelligent scientific instruments. Nat Methods (2025). https://doi.org/10.1038/s41592-025-02995-7
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DOI: https://doi.org/10.1038/s41592-025-02995-7