Supplementary Figure 10: Model of neural circuits that suppress fluid intake
From: Oxytocin-receptor-expressing neurons in the parabrachial nucleus regulate fluid intake
(a) Model of OxtrPBN neural circuitry illustrating OxtPVH projections to OxtrPBN neurons, likely projections from CCKNTS neurons to OxtrPBN neurons, and major OxtrPBN projections to CeA, BNST, OVLT, AVPV and MnPO. (b) OxtrPBN neurons are proposed to decrease or prevent hypernatremia ± hypervolemia by decreasing NaCl ± water intake. Inputs to OxtrPBN neurons arise from OxtPVH and NTS neurons. NTS neurons receive signals about volume and osmolarity status from peripheral baroceptors and visceral osmoreceptors (and likely from oropharyngeal and upper gastrointestinal receptors); while OxtPVH neurons receive signals from forebrain osmoreceptors and angiotensin II (ANG II). OxtPVH neurons project to PBN and can also release oxytocin peripherally to increase renal NaCl excretion. NTS neurons likely project to both OxtrPBN and CGRPPBN neurons, which can decrease NaCl, water and food intake
