Supplementary Figure 7: TIA1 reduction elicits a biphasic change in tau phosphorylation in PS19 mice | Nature Neuroscience

Supplementary Figure 7: TIA1 reduction elicits a biphasic change in tau phosphorylation in PS19 mice

From: Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

Supplementary Figure 7: TIA1 reduction elicits a biphasic change in tau phosphorylation in PS19 miceThe alternative text for this image may have been generated using AI.

A. IHC of DAPI (blue), NeuN (green), and CP13 phospho (S202)-tau (red) in 3 (top panels) and 6 (bottom) month CA3 in non-transgenic (WT Tau) and PS19 (P301S Tau) mice. B-C. Quantification of CP13 (from A) and AT8 (S202/T205) phospho-tau immunofluorescence at 3 months in CA1 and CA3. *p<0.05 **p<0.01 by unpaired Student's t-test (n=3-5/group). D. Quantification of CP13 immunofluorescence at 6 months in CA3 from A. **p=0.0044 by unpaired Student's t-test (n=4-5/group). Error bars represent means ± SEM.

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