Supplementary Figure 2: TIA1 reduction protects against presynaptic and axonal degeneration up to 9 months of age in P301S Tau mice | Nature Neuroscience

Supplementary Figure 2: TIA1 reduction protects against presynaptic and axonal degeneration up to 9 months of age in P301S Tau mice

From: Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

Supplementary Figure 2: TIA1 reduction protects against presynaptic and axonal degeneration up to 9 months of age in P301S Tau miceThe alternative text for this image may have been generated using AI.

A. IHC of NeuN (blue), synaptophysin (SYP, green), and neurofilament (NFL, red) in 9 month non-transgenic (WT Tau), PS19 (P301S Tau) and PS19 (P301S Tau) Tia1+/- hippocampus (CA3). Scale bar = 20 urn. B-C. Quantification of total SYP (B) and NFL (C) immunofluorescence in P301S Tia1+/+ and P301S Tia1+/- mice in A. SYP, unpaired Student's T-test (two-tailed) of P301S Tia1+/+ vs P301S Tia1+/-, *p=0.0491, N=10-13/group. NFL, unpaired Student's T-test (two-tailed) of P301S Tia1+/+ vs P301S Tia1+/-, *p=0.0441, N=11-12/group. Error bars denote means ± SEM normalized to wildtype levels equal to 1.

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