Supplementary Figure 5: Low enrichment of m6A on mRNAs encoding Ezh2, Suz12, and Eed m6A-meRIP-qPCR of Ezh2, Suz12, and Eed in Mettl14 KO vs. | Nature Neuroscience

Supplementary Figure 5: Low enrichment of m6A on mRNAs encoding Ezh2, Suz12, and Eed m6A-meRIP-qPCR of Ezh2, Suz12, and Eed in Mettl14 KO vs.

From: N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications

Supplementary Figure 5: Low enrichment of m6A on mRNAs encoding Ezh2, Suz12, and Eed m6A-meRIP-qPCR of Ezh2, Suz12, and Eed in Mettl14 KO vs.

control E14.5 NSCs. One-way ANOVA (n = 3 independent experiments for all experimental groups; Ezh2, P = 0.0812, F (2, 6) = 3.928; Suz12, P = 5.055E-06, F (2, 6) = 171.8; Eed, P = 0.00012, F (2, 6) = 57.32) followed by Bonferroni's post hoc test (Ezh2, WT vs. KO, P = 0.0739, 95% C.I. = −0.004323 to 0.08219, WT vs. Het, P =  = 0.1679, 95% C.I. = −0.0131 to 0.07341; Suz12, WT vs. KO, P = 3.125E-05, 95% C.I. = 0.2091 to 0.3387, WT vs. Het, P = 0.0029, 95% C.I. = −0.1855 to −0.05595; Eed, WT vs. KO, P = 9.828E-05, 95% C.I. = 0.02144 to 0.03883, WT vs. Het, P = 0.0823, 95% C.I. = −0.001105 to 0.01628). Graphs represent the mean ± SD. Dots represent data from individual data points. ns = non-significant. **** P < 0.0001.

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