Supplementary Figure 4: Associations between change in hippocampal volume and change in mean diffusivity in the HCB and UF. | Nature Neuroscience

Supplementary Figure 4: Associations between change in hippocampal volume and change in mean diffusivity in the HCB and UF.

From: Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals

Supplementary Figure 4: Associations between change in hippocampal volume and change in mean diffusivity in the HCB and UF.The alternative text for this image may have been generated using AI.

. The line plots (top row = left, bottom row = right hemisphere) show that change in right hippocampal volume over time predicted increased MD of the right HCB over time (left bottom corner; n=256 independent participants). No significant associations were found between change in hippocampal volume and changes in MD of the UF (n=253 independent participants). In all line plots, estimated marginal means of the moderation by change in hippocampal volume are plotted at the mean and ± 1 standard deviation, but analyses were done continuously using mixed-effects linear models. Shaded areas around the fit lines show the 95% confidence interval. All p-values are two-sided and unadjusted for multiple comparisons.

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