Supplementary Figure 9: Astrocytes, OPCs or neurons do not differentiate into microglia during repopulation. | Nature Neuroscience

Supplementary Figure 9: Astrocytes, OPCs or neurons do not differentiate into microglia during repopulation.

From: Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion

Supplementary Figure 9: Astrocytes, OPCs or neurons do not differentiate into microglia during repopulation.

(a) Scheme of fate mapping for the origin of repopulated microglia. (b-c) The rationale and hypotheses of tamoxifen triggered fate mapping. (d) Confocal images indicate no tdTomato-positive microglia in repopulated brains of GLAST-CreERT2::Ai14, NG2-CreER::Ai9, CaMK2a-CreERT2::Ai14, GAD2-CreER::Ai14 and TH-IRES-CreER::Ai14 mice, respectively. Each experiment has been independently repeated at least twice with similar results. PLX5622: PLX5622 formulated diet; CD: control diet; TAM: tamoxifen. Green: GFP; red: tdTomato.

Back to article page