Supplementary Figure 9: Astrocytes, OPCs or neurons do not differentiate into microglia during repopulation. | Nature Neuroscience

Supplementary Figure 9: Astrocytes, OPCs or neurons do not differentiate into microglia during repopulation.

From: Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion

Supplementary Figure 9: Astrocytes, OPCs or neurons do not differentiate into microglia during repopulation.The alternative text for this image may have been generated using AI.

(a) Scheme of fate mapping for the origin of repopulated microglia. (b-c) The rationale and hypotheses of tamoxifen triggered fate mapping. (d) Confocal images indicate no tdTomato-positive microglia in repopulated brains of GLAST-CreERT2::Ai14, NG2-CreER::Ai9, CaMK2a-CreERT2::Ai14, GAD2-CreER::Ai14 and TH-IRES-CreER::Ai14 mice, respectively. Each experiment has been independently repeated at least twice with similar results. PLX5622: PLX5622 formulated diet; CD: control diet; TAM: tamoxifen. Green: GFP; red: tdTomato.

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