Supplementary Figure 2: SWDs occur in cortical S1 earlier than in VB and other cortical regions of GAERS. | Nature Neuroscience

Supplementary Figure 2: SWDs occur in cortical S1 earlier than in VB and other cortical regions of GAERS.

From: Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures

Supplementary Figure 2

(a) EEG traces showing the start of a GAERS bilateral SWD in the perioral region of the primary somatosensory cortex (S1) before the ventrobasal thalamic nucleus (VB), the primary motor cortex (M1), the primary auditory cortex (A1) and the medial prefrontal cortex (mPFC). (b) Left: difference in the start time of SWDs between the recorded areas (the start of the SWDs in S1 is taken as time zero). Note the statistically significant delay in the start time between S1 (p=8.1x10−17, n=41, two-sided Mann-Whitney U test) and VB, and between VB and the other cortical areas (p=4.8x10−5, n=41, two-sided Mann-Whitney U test). Points are mean and error bars are ±SEM. Right: lack of any significant difference in the start of SWDs between the right and left hemisphere in the brain regions examined (p=0.9, 0.95, 0.89, 0.95 and 0.99, n=41, two-sided Mann-Whitney U test). Values are mean±SEM. (c) Superimposed cross-correlograms of SWC-spikes show no time-lag among left and right hemispheres for different brain regions (n= 41 SWDs in 3 GAERS for b and c).

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