Supplementary Figure 9: Action potential classification and firing dynamics of GAERS cortical putative excitatory neurons. | Nature Neuroscience

Supplementary Figure 9: Action potential classification and firing dynamics of GAERS cortical putative excitatory neurons.

From: Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures

Supplementary Figure 9

(a) EEG trace (top) and raster plots (bottom) showing SWDs and firing times, respectively, of simultaneously recorded single cortical and TC neurons. (b) High-pass filtered traces showing typical isolated cortical action potentials. (c) Auto-correlogram of a putative excitatory cortical neuron. (d) Action potential half-widths vs trough-to-peak times for putative inhibitory (n=5) (black, FS for fast-spiking) and excitatory (n=41) (red, RS for regular spiking) cortical neurons. Average action potential waveforms are shown in the inset. (e) Total firing rate of all cortical pyramidal neurons (n=41). Horizontal dashed line indicates the start and end of SWDs in the EEG. Lines are mean and shaded areas are ±SEM. (f) XCors of total firing of 3 simultaneously recorded cortical excitatory neurons during interictal periods (black) and ASs (red). (g) Cumulative distributions of the peak of total firing for all simultaneously recorded cortical excitatory (n=41) and TC (n=43) neurons show no difference between the two neuronal populations (p=0.4892, Kolmogorov-Smirnov test).

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