Supplementary Figure 11: Effect of bilateral microdialysis application of TTA-P2 on the number and duration of ASs in GAERS. | Nature Neuroscience

Supplementary Figure 11: Effect of bilateral microdialysis application of TTA-P2 on the number and duration of ASs in GAERS.

From: Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures

Supplementary Figure 11

(a) Each plot show the effect of TTA-P2 applied in the indicated brain regions (c and m indicate central to the VB and medial to the VB, respectively) on the mean number of ASs and mean length of individual seizures (from left to right and top to bottom: n=7, 6, 10, 9, and 16 animals, p=0.742, 0.547, 1, 0.031, 0.014, 0.024, 1, 0.313, 0.433, 0.013, paired two-sided Wilcoxon signed-rank test). (b) Effect of TTA-P2 applied in the indicated brain regions on the mean peak frequency of SWDs for the same groups of animals, compared to vehicle microdialysis application (from left to right: n=7, 6, 7, 8, and 16 animals, p=0.563, 0.438, 0.625, 0.945, 0.025, paired two-sided Wilcoxon signed-rank test). In all subfigures, black lines are mean and error bars are ±SEM.

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