Supplementary Figure 6: Diazepam administered i.c.v. prevents the DE-mediated increase in GluN2B function.
From: Two distinct mechanisms for experience-dependent homeostasis
(A) DE increased the percentage of NMDAR EPSC blocked by ifenprodil (*P=0.021, 2-tailed t test) and the NMDA receptor decay constant (τw) (†P=0.002, 2-tailed t test) in animals with no drug administration. (B) In DE animals, diazepam prevented the GluN2B increase compared to vehicle (*P=0.039; †P=0.030; 2-tailed t test). Solid lines: average baseline NMDAR current; dashed lines: after ifenprodil wash-in. Traces are normalized to baseline. Data are displayed as individual points; dashed lines indicate average (±SEM); sample size is shown as (neurons, mice)
