Supplementary Figure 2: Sharp wave ripple event detection. | Nature Neuroscience

Supplementary Figure 2: Sharp wave ripple event detection.

From: Altered hippocampal replay is associated with memory impairment in mice heterozygous for the Scn2a gene

Supplementary Figure 2

(a) Upper traces (WB) show five examples of raw CA1 stratum pyramidale local field potentials recorded from control mice during a rest period in a small sleep box. Blue traces represent activity centered on events detected as SPW-Rs, with the period detected as a ripple (as described in the methods section) highlighted in red. Below these are the same LFPs band-pass filtered between 80–200 Hz. The bottom panel shows multi-unit activity of all clustered place cells for the corresponding time periods. (b) Shows the same but for Scn2a+/- mice. Scale bars represent 100 ms (horizontal) and 100 µV (vertical) throughout.

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