Supplementary Figure 9: Graphical summary.

Pathological tau disrupts heterochromatin- and piRNA-mediated transposable element silencing. Activation of transposable elements promotes aberrant activation of the cell cycle in post-mitotic neurons, which is sufficient to induce neuronal death. A nucleoside analog inhibitor of reverse transcriptase, 3TC, as well as dietary restriction suppress transposable element dysregulation in tauopathy, and decrease tau-induced neurotoxicity