Supplementary Figure 2: Fmr1–/– mice are delayed in suppressing the no-go response (corresponds to data in Fig. 1e). | Nature Neuroscience

Supplementary Figure 2: Fmr1–/– mice are delayed in suppressing the no-go response (corresponds to data in Fig. 1e).

From: Impaired perceptual learning in a mouse model of Fragile X syndrome is mediated by parvalbumin neuron dysfunction and is reversible

Supplementary Figure 2

a. Sample behavioral data for a representative WT mouse (top) and Fmr1-/- mouse (bottom) over 100 trials in session #1 vs. Session #4. Only ‘Hit’, ‘false alarm’ (FA) and ‘correct rejection (CR) responses are shown. Note how the WT animal is able to suppress the FA responses and increase the proportion of CR responses by session #4, whereas there is virtually no change in response characteristics for the Fmr1-/- animal between session #1 and session #4. However, by the learned session (session #7), the Fmr1-/- mouse has suppressed its FA responses. b. Profile of proportion of Hit, CR, FA and Miss responses over the course of training. Hit: F4,156 = 1.05, p = 0.03, CR: F4,156 = 2.29, p = 0.1 × 10-3; Miss: F4,156 = 2.99, p = 0.5 × 10-5; FA: F4,156 = 2.53, p = 0.4 × 10-5; Friedman test with repeated measures on training. Two-sided Mann-Whitney tests (genotypes), p-values shown on the Figure.

Back to article page