Supplementary Figure 2: Spatial distribution of HFA. | Nature Neuroscience

Supplementary Figure 2: Spatial distribution of HFA.

From: Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

Supplementary Figure 2

(a) Averaged normalized power spectra of interictal signals in the isolated CA1 demonstrate a clear peak in the high-frequency band due to the presence of HFA. (b) Recording with multiple electrodes demonstrated that HFA was present across the entire CA1. Normalized power spectra in each region were color-coded to display the spatial properties of the spectral profile. (c) Mean power spectra of the signal recorded in CA1 of the intact hippocampus between seizures. (d) Spatial analysis of the spectral profile also demonstrates the presence of HFA in the entire CA1 region. The HFA peak is around 180 Hz, while lower frequency peaks correspond to spectral components of IEDs. (n=10 isolated CA1 slices, and n=10 intact hippocampal slices).

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