Supplementary Figure 4: The laminar profile of IEDs. | Nature Neuroscience

Supplementary Figure 4: The laminar profile of IEDs.

From: Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

Supplementary Figure 4

(a) IEDs triggered in the CA3 propagate to the CA1 where they induce IEDs. (b,c) Current source density analysis reveals that CA1 IEDs are due to a current sink at the region of the middle apical dendrites and basal dendrites flanked by sources in the distal radiatum as well as the pyramidale. The slow wave following the IEDs is characterized by sources in the same regions with a passive sink in the somatic region. Observed current source density profile suggests that at the cellular level the IEDs in CA1 are due to postsynaptic excitation at the middle part of apical dendrites.

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