Supplementary Figure 6: The complex effect of interictal perturbations on the transition to seizure in the modified Epileptor model.

(a) The transition between interictal state and seizure in the Epileptor model is characterized by a saddle-node bifurcation. (b) The Epileptor model captures both slow processes and faster dynamics, replicating local field potentials during seizure respectively. (c,d) Introduction of less frequent but stronger interictal perturbations increases the probability of the transition to seizure. (e,f) Increasing the frequency of perturbations decreases the probability of the transition to seizure, or it can result in complete cessation of seizures (g,h). (i) Map of combinations of perturbation parameters, i.e. frequency and amplitude and their resulting impact on ictogenesis.