Supplementary Figure 8: Schematic diagram of the reciprocal activation between SOX2 and Notch signaling determining the WM tract tropism of GSCs. | Nature Neuroscience

Supplementary Figure 8: Schematic diagram of the reciprocal activation between SOX2 and Notch signaling determining the WM tract tropism of GSCs.

From: Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1–SOX2 positive-feedback loop

Supplementary Figure 8

CD133 and Notch1 double-positive GSCs were preferentially located along the Notch ligand Jagged1 expressed WM tracts, which. exhibited a demyelinated phenotype, at the invasive frontier of glioma tissues. The Notch-induced transcription factor Sox9 promoted. the transcription of SOX2 and the methylation level of the NOTCH1 promoter was attenuated by the upregulation of SOX2 to reinforce. NOTCH1 expression in GSCs

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