Supplementary Figure 5: SarkoSpin extracts from different ALS and FTLD samples have distinct protein compositions beyond TDP-43. | Nature Neuroscience

Supplementary Figure 5: SarkoSpin extracts from different ALS and FTLD samples have distinct protein compositions beyond TDP-43.

From: TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates

Supplementary Figure 5: SarkoSpin extracts from different ALS and FTLD samples have distinct protein compositions beyond TDP-43.

Abundance levels of selected proteins that were most consistently different in patient samples of human TDP-43 proteinopathies, FTLD-Tau (FTLD-T) and controls. We applied the idealized vector method described in the Methods section for control and pooled TDP-43 proteinopathy samples (ALS, FTLD-TDP-A, FTLD-TDP-B and FTLD-TDP-C): a vector of the same number of 0s as control samples and the same number of 1s patient samples was created. For each protein, we measured the correlation of this idealized vector to the vector of normalized and batch-corrected protein abundance values of control and patient samples. The top 50 correlating proteins were sorted based on these correlation values, which are shown as a bar plot on the right. Strong correlation values (r > 0.5) were separated from medium and weak correlation values by the red dashed line.

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