Supplementary Figure 1: Characteristics of disease subtypes and correlation to disease duration. | Nature Neuroscience

Supplementary Figure 1: Characteristics of disease subtypes and correlation to disease duration.

From: TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates

Supplementary Figure 1: Characteristics of disease subtypes and correlation to disease duration.

a. Phosphorylated TDP-43 immunohistochemical staining of temporal cortex from FTLD-TDP subtypes, highlighting differences in their pathological hallmarks. Neuronal cytoplasmic inclusions (NCI) (arrows) and short dystrophic neurites (DN) (arrowhead) were observed in FTLD-TDP-A without (top panel) or with (middle panel) C9orf72 repeat expansions. In FTLD-TDP-C, long twisted neurites were observed (lower panel, arrowhead). Scale bar 25 μm. This experiment was repeated two independent times with similar results. b-c. Age at death (b) and disease duration (c) of patients from the different disease groups used in the study (error bars show means and SD). FTLD-TDP-C patients showed significantly longer disease duration. n = 16, 25 and 11 individual patients for ALS, FTLD-TDP-A and FTLD-TDP-C respectively. One-way ANOVAs followed by Tukey’s multiple-comparison tests gave the indicated p values.

Back to article page