Supplementary Figure 7: Amygdala structure and value computation contribute to PTSD symptoms using a Rescorla–Wagner model.
From: Neural computations of threat in the aftermath of combat trauma
a. Regions of interest used in the computational imaging analysis. The amygdala (red) was defined functionally, using the contrast of conditioned stimulus vs. baseline. b-d. Amygdala volume and value-dependent neural activity independently contribute to PTSD symptoms. Partial correlations are shown (N = 54 participants) with Pearson correlation coefficients and two-tailed significance tests. Right amygdala volume and activity as well as left amygdala activity correlated negatively with the PTSD symptoms as measured with the CAPS. Regressions were adjusted for learning rate, age, gender, head movement, and total intracranial volume. Error shadings correspond to standard errors. CAPS, Clinician-Administered PTSD Scale; adj., adjusted; **, P < 0.01; *, P < 0.05.
