Supplementary Figure 2: Silencing extinction- and fear acquisition-tagged neurons has no effect during second light ON and OFF epochs.
From: Distinct hippocampal engrams control extinction and relapse of fear memory
(a-c) From extinction-tagged neuron silencing experiment (Fig. 3). Silencing extinction-tagged neurons had no effect on freezing behavior during the second light ON and OFF epochs during (a) extinction retrieval test, (b) alternate context test, and (c) spontaneous recovery test. ArcCreERT2(-): n = 9 mice; ArcCreERT2(+): n = 9 mice. (d-f) From fear-tagged neuron silencing experiment (Fig. 4). Silencing fear-tagged neurons had no effect on freezing behavior during the second light ON and OFF epochs during (d) extinction retrieval test, (e) alternate context test, and (f) spontaneous recovery test. ArcCreERT2(-): n = 8 mice; ArcCreERT2(+): n = 7 mice. Data are means ± s.e.m. See Supplementary Table 1 for statistics.
