Supplementary Figure 3: Silencing extinction-tagged neurons impairs extinction retrieval in second extinction retrieval test.
From: Distinct hippocampal engrams control extinction and relapse of fear memory
(a) Experimental design. Second extinction retrieval test occurred 1 d after the alternate context test. Same animals from Fig. 3. (b) Freezing behavior during the second extinction retrieval test. (c) Silencing extinction-tagged neurons increased freezing in ArcCreERT2(+) mice during the first light ON and light OFF epochs compared to ArcCreERT2(-) mice. ArcCreERT2(-): n = 9 mice; ArcCreERT2(+): n = 9 mice. Data are means ± s.e.m. See Supplementary Table 1 for statistics. * p < 0.05, ** p < 0.01.
