Supplementary Figure 5: Relationship between delay-period activity and predictive licking on operant trials.

a. Example of microzone from animal that exhibited predictive licking showing delay period activity on both correct (left, black) and incorrect (right, red) trials. N = 162 correct trials and 124 incorrect trials. b. Same as panel a but for animal that did not exhibit predictive licking. N = 156 correct trials and 115 incorrect trials. c. Comparison of mean microzonal activity during delay period (-500 to 0 ms relative to reward) in significantly activated microzones on correct and incorrect trials. Dots of the same color represent microzones from the same recording. N = 14 microzones from 6 mice. d. Comparison of degree of predictive licking on correct and incorrect trials. N = 6 sessions from 6 mice. e. Relationship between level of delay period activation and degree of predictive licking on correct trials. N = 14 microzones from 6 mice. f. Same as panel e but for incorrect trials. Traces in panels a and b and data points in panels d-f are shown as mean ± s.e.m. Black line and shaded bars in panels d-f represent linear fit and 95% confidence interval through all data points (linear regression; panel c, p = 2 × 10−6; panel d, p = 5 × 10−8; panel e, p = 0.5; panel f, p = 0.9).