Supplementary Figure 8: Extended data from Fig. 5. Sfrp1 inactivation critically delays the appearance of amyloid plaques in APP;PS1 mice. | Nature Neuroscience

Supplementary Figure 8: Extended data from Fig. 5. Sfrp1 inactivation critically delays the appearance of amyloid plaques in APP;PS1 mice.

From: Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer’s disease pathogenesis

Supplementary Figure 8

A) Quantification of the size distribution of Aβ+ APs illustrated in Fig. 5a–f. Note the significant decrease in the size of Aβ+ hotspots in Sfrp1 absence. Data are means ± SEM analyzed with two-sided Student-t test. B-E, G,H) Frontal cryostat sections of the cortex from 4.5, 9 and 20 months-old APP;PS1 and APP;PS1;Sfrp1-/- mice stained with ThioS as indicated in the panels. F) Quantification of the number of ThioS+ APs in 4.5 (n=6, both genotypes), 9 (n=4, both genotypes) and 20 (n=3, both genotypes) months-old APP;PS1 and APP;PS1;Sfrp1-/- mice. I-M) Frontal sections of the cortex from a different set of 4.5 and 9 months-old APP;PS1 and APP;PS1;Sfrp1-/- mice stained with antibodies against Aβ40-42. K) Quantification of the number of Aβ40-42+ APs in 4.5 (n=6, both genotypes), 9 (n=4, both genotypes) APP;PS1 and APP;PS1;Sfrp1-/- mice. *p≤0.05; **p≤0.01; ***p≤0.001. Scale bar: 100 μm.

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