Supplementary Figure 12: Extended data from Fig. 6. Behavioral analysis of wt, Sfrp1-/-, APP;PS1 and APP;PS1 Sfrp1-/- mice. | Nature Neuroscience

Supplementary Figure 12: Extended data from Fig. 6. Behavioral analysis of wt, Sfrp1-/-, APP;PS1 and APP;PS1 Sfrp1-/- mice.

From: Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer’s disease pathogenesis

Supplementary Figure 12

A-C) The graphs depict the recognition index (A), spatial memory retention (B) and number of crossing (C) of wt (n=4) and Sfrp1-/- (n=4) 8 months-old mice subjected to the object recognition test, water maze and open field exploration, respectively. Note that the behavior of Sfrp1-/- mice was undistinguishable from that of wt mice. D, E) The graphs depict the time in quadrant (D) and number of crossing (E) of wt (n=6), APP;PS1 (n=5) and APP;PS1;Sfrp1-/- (n=6) of 8 months-old mice subjected to water maze and open field exploration, respectively. Note that APP;PS1 mice showed a poor memory, whereas APP;PS1;Sfrp1-/- mice were undistinguishable from wt. APP;PS1;Sfrp1-/- mice showed a slightly lower locomotor performance. Data are means ± SEM analyzed with two-sided Student-t test (A-C) or One-way ANOVA followed by Tukey method (D-E). *p≤0.05.

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