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NEURODEGENERATION

Connectomics of neurodegeneration

Nature Neuroscience volume 22, pages 1200–1202 (2019)Cite this article

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Misfolded protein aggregates are a classical hallmark of many neurodegenerative diseases. By combining a mouse model of misfolded protein injection and a brain network model of misfolded protein diffusion, a study now finds a strong link between the stereotypical spreading patterns of neurodegeneration, protein expression and anatomical connectivity.

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Fig. 1: Network modeling of neurodegeneration.

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Authors and Affiliations

  1. Department of Mechanical Engineering and Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA

    Ellen Kuhl

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  1. Ellen Kuhl
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Correspondence to Ellen Kuhl.

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The author declares no competing interests.

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Kuhl, E. Connectomics of neurodegeneration. Nat Neurosci 22, 1200–1202 (2019). https://doi.org/10.1038/s41593-019-0459-3

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