Supplementary Fig. 2: Training results for NMDAR and I-V experiments in Fig. 1.
From: Silent synapses dictate cocaine memory destabilization and reconsolidation
(a-d) Self-administration training results of rats whose electrophysiology results are presented in Fig. 1n, o (saline 1w/d: infusions – d1 = 17.00 ± 3.62, d2 = 9.40 ± 2.54, d3 = 2.40 ± 3.12, d4 = 11.00 ± 3.08, d5 = 15.50 ± 4.29, inactive – d1 = 12.40 ± 2.50, d2 = 7.80 ± 1.32, d3 = 9.20 ± 2.04, d4 = 8.40 ± 3.44, d5 = 10.75 ± 3.95, n = 5 animals; cocaine 1w/d: infusions – d1 = 42.20 ± 11.43, d2= 32.00 ± 8.06, d3= 39.40 ± 9.88, d4= 40.40 ± 7.94, d5= 41.60 ± 7.71, inactive – d1= 20.40 ± 7.81, d2= 30.60 ± 9.94, d3= 13.00 ± 4.37, d4= 10.60 ± 2.93, d5 = 12.00 ± 3.65, n = 5 animals; saline 45w/d: infusions – d1= 17.00 ± 3.46, d2= 9.33 ± 6.33, d3= 5.33 ± 2.85, d4= 9.67 ± 5.67, d5= 10.67 ± 1.33, inactive – d1= 19.00 ± 8.02, d2= 8.33 ± 4.49, d3= 4.00 ± 3.06, d4= 7.00 ± 1.53, d5= 7.67 ± 2.33, n = 3 animals; cocaine 45w/d: infusions – d1= 33.00 ± 6.78, d2= 26.00 ± 1.92, d3= 26.00 ± 2.30, d4 = 28.40 ± 4.20, d5= 23.40 ± 1.83, inactive – d1 = 14.80 ± 3.76, d2= 15.00 ± 5.06, d3= 11.00 ± 1.30, d4= 11.20 ± 2.29, d5= 11.00 ± 4.55, n = 5 animals; cocaine re-exp: infusions – d1= 30.60 ± 4.76, d2= 28.80 ± 3.06, d3= 26.00 ± 2.67, d4= 30.20 ± 2.76, d5 = 31.20 ± 3.29, inactive – d1= 21.60 ± 14.94, d2= 7.20 ± 3.84, d3= 6.40 ± 3.36, d4 = 9.20 ± 2.65, d5= 8.00 ± 1.41, n = 5 animals). (d, right). Nose poke responding during the cue re-exposure session of rats whose electrophysiology results are presented in Fig. 1o (37.80 ± 7.70, n = 5 animals). (e,f) Self-administration training results of rats whose electrophysiology results are presented in Fig. 1p, q (saline: infusions – d1= 15.50 ± 2.39, d2= 10.67 ± 2.97, d3= 7.83 ± 2.97, d4= 9.50 ± 2.66, d5=8.00 ± 1.34, inactive – d1 = 15.00 ± 4.26, d2= 9.67 ± 2.28, d3= 7.00 ± 2.56, d4= 8.17 ± 1.17, d5= 6.17 ± 1.62, n = 6 animals; cocaine 45w/d: infusions – d1= 35.00 ± 11.24, d2= 26.00 ± 2.76, d3= 26.80 ± 2.81, d4= 28.20 ± 4.66, d5= 28.20 ± 2.46, inactive – d1= 15.80 ± 4.58, d2= 10.40 ± 2.29, d3= 9.20 ± 1.56, d4= 8.20 ± 2.56, d5= 12.00 ± 4.99, n = 5 animals; cocaine re-exp: infusions – d1= 45.75 ± 18.54, d2= 27.50 ± 2.40, d3= 23.25 ± 3.59, d4= 24.40 ± 5.39, d5= 25.25 ± 5.14, inactive – d1= 21.00 ± 11.23, d2= 13.75 ± 7.42, d3= 5.75 ± 2.59, d4= 5.25 ± 3.25, d5= 3.25 ± 2.29, n = 4 animals). (f, right). Nose poke responding during the cue re-exposure session of rats whose electrophysiology results are presented in Fig. 1p, q (20.50 ± 3.57, n = 4 animals). Data presented as mean±SEM.
