Extended Data Fig. 5: Phosphorylated α-syn (PSyn) deposition in the midbrain and hypothalamus of TgM83 mice injected with various α-syn strains.
From: α-Synuclein strains target distinct brain regions and cell types
a) Representative immunohistochemistry images for PSyn in midbrain and hypothalamus sections from asymptomatic TgM83 mice following inoculation with either PBS or monomeric α-syn, or from clinically ill mice inoculated with either the S fibril- or NS fibril-derived strains (first, second, or third passage). Scale bar = 50 μm (applies to all images). dpi, days post-inoculation. b) Representative immunohistochemistry images for PSyn in midbrain and hypothalamus sections from asymptomatic uninoculated TgM83 mice, or from clinically ill mice inoculated with either the MSA- or M83+/+-derived strains (first or second passage). Scale bar = 50 μm (applies to all images).
