Extended Data Fig. 10: Absence of PSyn pathology in TgM83 mice inoculated with brain extract from a DLB patient or an AD patient with concomitant α-syn deposition. | Nature Neuroscience

Extended Data Fig. 10: Absence of PSyn pathology in TgM83 mice inoculated with brain extract from a DLB patient or an AD patient with concomitant α-syn deposition.

From: α-Synuclein strains target distinct brain regions and cell types

Extended Data Fig. 10: Absence of PSyn pathology in TgM83 mice inoculated with brain extract from a DLB patient or an AD patient with concomitant α-syn deposition.

a) Thermolysin digestion of brain extracts from the three human synucleinopathy samples inoculated into TgM83 mice. α-Syn was detected using the antibody Syn-1. b) Semiquantitative PSyn deposition scoring (data are mean ± s.e.m.) within the indicated brain regions from asymptomatic TgM83 mice at 540 days following inoculation with PBS (first passage, n = 7), DLB brain extract (n = 5), or AD brain extract (n = 4). c) Representative immunohistochemistry images for PSyn in midbrain and hypothalamus sections from asymptomatic TgM83 mice following inoculation with DLB or AD brain extract. Scale bar = 50 μm (applies to all images).

Source data

Back to article page