Extended Data Fig. 4: Synaptophysin expression in the hilus of patients. | Nature Neuroscience

Extended Data Fig. 4: Synaptophysin expression in the hilus of patients.

From: Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease

Extended Data Fig. 4: Synaptophysin expression in the hilus of patients.

a, Photomicrographs showing Synaptophysin immunostaining in the hilus of CTRL or AD donors. b, Histogram showing the intensity of Synaptophysin staining in CTRL or AD donors. c, Correlation plot between the intensity of Synaptophysin staining and the number of hilar astrocytes expressing 3R tau in AD patients. d, Correlation plot between the intensity of Synaptophysin staining and the number of hilar astrocytes expressing 4R tau in AD patients. N=patients/sections per patient; N = 9/4 for Control, N = 6/4 for AD (P-Tau−/Aβ-), N = 6/4 for AD (P-Tau+/Aβ-), N = 8/4 for AD (P-Tau+/Aβ+), (b-d). One-sided ANOVA with Tukey’s post-hoc test (b) and two-tailed Spearman’s rank non-parametric correlation test (c, d). Data are presented as the mean ± SEM. Scale bar: 25 µm.

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