Extended Data Fig. 1: Differential Aβ accumulation in the hilus of AD patients. | Nature Neuroscience

Extended Data Fig. 1: Differential Aβ accumulation in the hilus of AD patients.

From: Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease

Extended Data Fig. 1

a, Histogram showing the age of patients. b, Histogram showing the post-mortem delay of patients. c, Histogram showing the sex of patients. d, Photomicrographs of the human hippocampus showing the density of Aβ in healthy patient and AD donors. The different areas are indicated as black overlay. e, Histogram showing the density of Aβ in the different hippocampal regions of healthy and AD donors. f, Correlations between Aβ plaques density and Braak stage for patients, for each hippocampal area. g, Table showing the correlation values and P values. Scale bars: 250 µm (d). N = patients/sections per patient; N = 9/4 for Control, N = 6/4 for AD (P-Tau−/Aβ-), N = 6/4 for AD (P-Tau+/Aβ-), N = 9/4 for AD (P-Tau+/Aβ+), (a-c,e-g). One-sided ANOVA with Tukey’s post-hoc test (a-c), Mann-Whitney two-tailed t-test (e) and two-tailed Spearman’s rank non-parametric correlation test (g). Data are presented as the mean ± SEM.

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