Extended Data Fig. 8: Antibody depletion of NK cells in aged mice. | Nature Neuroscience

Extended Data Fig. 8: Antibody depletion of NK cells in aged mice.

From: Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition

Extended Data Fig. 8: Antibody depletion of NK cells in aged mice.

Anti-NK1.1 mAb (PK136) was used to deplete NK cells. 100 μg of anti-NK1.1 mAb was injected i.p. into each mouse every 5 days until the end of experiments. Single-cell suspensions were prepared from blood or brain tissues of male aged mice receiving anti-NK1.1 mAb or IgG control. a-b, Flow cytometry analysis of NK cell counts in blood (a) and brain (b) of aged (18 months) mice receiving anti-NK1.1 mAb or IgG control. n = 5 per group. **p<0.01 by two-tailed unpaired Student’s t-test. In a, p<0.0001, t=10.76, df=8. In b, p=0.0002, t=6.632, df=8. Data are representative of three independent experiments. Error bars represent s.e.m.

Back to article page