Extended Data Fig. 9: Absence of NKT cells does not affect neurogenesis and cognitive function in aged mice. | Nature Neuroscience

Extended Data Fig. 9: Absence of NKT cells does not affect neurogenesis and cognitive function in aged mice.

From: Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition

Extended Data Fig. 9

a, Immunostaining reveals the counts of Nestin+ neural stem cells and DCX+ neuroblasts in dentate gyrus tissues of male aged (18 months) wild type and CD1d-/- (devoid of NKT cells) mice. n = 6 per group. b, Spatial memory performance was measured in aged (18 months) wild type and CD1d-/- mice using Morris water maze. Bar graph shows swimming velocity in indicated groups of mice. n = 6 per group. c, Cumulative data plots show swimming distance of aged wild type and CD1d-/- mice. Swimming distance summary was from beginning to the end of each trial session from day 1 to 4. Images show swimming traces of indicated groups during the probe test at day 5. n = 14 per group. d-e, Quantification of time spent in the northeast quadrant during the probe test (d) and target-platform crossing times (e). In d-e, n = 14 mice per group. Data are representative of three independent experiments. Error bars represent s.e.m.

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