Fig. 4: Colocalization of SARS-CoV spike protein with neural/neuronal cells in distinct olfactory mucosa samples from individuals with COVID-19. | Nature Neuroscience

Fig. 4: Colocalization of SARS-CoV spike protein with neural/neuronal cells in distinct olfactory mucosa samples from individuals with COVID-19.

From: Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

Fig. 4

a–l, Representative maximum-intensity projections of confocal (a–d and i–l) or epifluorescence (e–h) microscopy images of olfactory mucosa showing intracytoplasmic staining for SARS-CoV S protein within TuJ1+ (a–d, individual P27), NF200+ (e–h, individual P27) and OMP+ (i–l, individual P27) OSNs. Staining for TuJ1, NF200 and OMP (magenta, Alexa Fluor 488) marks cells of neuronal origin, staining for SARS-CoV S protein (yellow, Alexa Fluor 555) visualizes the presence of SARS-CoV and DAPI staining (petrol) identifies all cell nuclei (n = 3 individuals with COVID-19 (P27, P30 and P32) were analyzed; n = 2 individuals without COVID-19 served as controls; shown are representative images from P27). Scale bars, (all panels) 10 µm.

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